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Titlebook: Research in Computational Molecular Biology; 20th Annual Conferen Mona Singh Conference proceedings 2016 Springer International Publishing

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Multitask Matrix Completion for Learning Protein Interactions Across Diseasesrmance over prior state-of-the-art models. We show how our model’s parameters can be interpreted to reveal both general and specific interaction-relevant characteristics of the viruses. Our code, data and supplement is available at: ..
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MetaFlow: Metagenomic Profiling Based on Whole-Genome Coverage Analysis with Min-Cost Flowspecies level are two to four times better in terms of .-norm. On a real human stool data set, MetaFlow identifies . as most predominant, in line with previous human gut studies, whereas marker-based methods report it as rare. MetaFlow is freely available at ..
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LUTE (Local Unpruned Tuple Expansion): Accurate Continuously Flexible Protein Design with General En flexibility and general, possibly non-pairwise energy functions to an arbitrary level of accuracy using a discrete energy matrix. We show using 47 design calculation test cases that LUTE provides a dramatic speedup in both single-state and multistate continuously flexible designs.
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0302-9743 from 172 submissions. 20 short abstracts are included inthe back matter of the volume. They report on original research in all areas ofcomputational molecular biology and bioinformatics..978-3-319-31956-8978-3-319-31957-5Series ISSN 0302-9743 Series E-ISSN 1611-3349
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Structural Variation Detection with Read Pair Information—An Improved Null-Hypothesis Reduces Biashich agrees with data. From this model we derive an improved null hypothesis that, when applied in the variant caller CLEVER, reduces the number of false positives and corrects a bias that contributes to more deletion calls than insertion calls. A reference implementation is freely available at ..
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Conference proceedings 2016CA, USA, inApril 2016...The 15 regular papers presented in this volume were carefullyreviewed and selected from 172 submissions. 20 short abstracts are included inthe back matter of the volume. They report on original research in all areas ofcomputational molecular biology and bioinformatics..
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