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Titlebook: Reoviruses: Entry, Assembly and Morphogenesis; Polly Roy Book 2006 The Editor(s) (if applicable) and The Author(s), under exclusive licens

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0070-217X s a model system for the other members of the family. Indeed, most of our initial understanding of molecular biology and processes involved in virus replication and pathogenesis for the members of the family was generated from reovirus studies. With this platform two other members of the family caus
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Book 2006he family. Indeed, most of our initial understanding of molecular biology and processes involved in virus replication and pathogenesis for the members of the family was generated from reovirus studies. With this platform two other members of the family causing disease in human and/or animals have ga
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Rotavirus Genome Replication and Morphogenesis: Role of the Viroplasm,tion on the development and organization of viroplasms, the structure and function of its components, and interactive pathways linking RNA synthesis and capsid assembly provide new insight into how these microenvironments serve to interface the replication and morphogenetic processes of the virus.
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Attachment and Cell Entry of Mammalian Orthoreovirus,ut cause disease only in the very young. Prototype strains of the three reovirus serotypes differ in pathogenesis following infection of newborn mice. Reoviruses are nonenveloped, icosahedral particles that consist of ten segments of double-stranded RNA encapsidated within two protein shells, the in
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Early Steps in Rotavirus Cell Entry,ntric layers of protein that enclose a genome of double-stranded RNA. These viruses have a specific cell tropism in vivo, infecting primarily the mature enterocytes of the villi of the small intestine. It has been found that rotavirus cell entry is a complex multistep process, in which different dom
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Early Steps in Avian Reovirus Morphogenesis,ral and four nonstructural proteins, three of them encoded by the S1 gene. These viruses enter cells by receptor-mediated endocytosis, and acidification of virus-containing endosomes is necessary for the virus to uncoat and release transcriptionally active cores into the cytosol. Avian reoviruses re
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