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Titlebook: Renal Pharmacology; Manuel Martinez-Maldonado Book 1978 Springer Science+Business Media New York 1978 biochemistry.kidney.pharmacology.phy

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Methodology for Enzymatic Studies of Isolated Tubular Segments: Adenylate Cyclase,tion. At the level of the cell membrane, adenylate cyclase is involved in the transduction of the extracellular signal provided by the hormone for the intracellular production of cyclic AMP. In the cell interior, cyclic AMP is responsible for inducing the appropriate biological response, and was acc
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Methodology for Study of Isolated Perfused Dog Kidney ,,inants of renal function. The pump perfused isolated kidney technique of Richards and Drinker (1915) and the heart-lung-kidney preparation of Starling and Verney (1925) testify to the high level of sophistication and ingenuity in isolated organ perfusion achieved by investigators of that period. Con
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Methodology for Study of Isolated Perfused Dog Kidney ,, and Schmiedeberg, 1877). Jacobj (1890) utilized a pump-oxygenator system and defibrinated blood; although the urine secreted proved to be different from a transudate (Jacobj and Sobieranski, 1892), the functional performance was poor and the blood flow was very low because of an intense vasoconstri
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Methodology for Study of Isolated Perfused Rat Kidney ,,els, and the absence of modifying effects from other organs are primary benefits. In the case of the kidney, a further advantage accrues from the fact that transport events transpire while the perfused tissue is being studied. For an organ in which the major energy expenditure is believed to be for
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Methodology for Study of Isolated Perfused Rat Kidney ,, that transport events transpire while the perfused tissue is being studied. For an organ in which the major energy expenditure is believed to be for transport (a process that occurs to only a limited extent in slices and not at all in homogenates), this is an important consideration.
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Morphological Techniques for Study of the Kidney,ron segments (Schwartz and Venkatachalam, 1974; Whittembury and Rawlins, 1971). Hence, exploitation of anatomical techniques becomes an important if not obligatory component of pathophysiological studies of the kidney.
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