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Titlebook: Renal Pathology in Biopsy; Light, Electron and Hans Ulrich Zollinger,Michael Jörg Mihatsch Book 1978 Springer-Verlag Berlin · Heidelberg 1

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General Aspects of Glomerulonephritislassification is currently possible for many diseases such as GN. A more attainable goal would be a classification of GN from the pathogenetic point of view, but even this approach remains generally unsuccessful (e.g., systemic diseases such as SLE, Schönlein Henoch’s purpura, vasculitis, etc.).
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Foccally Accentuated Glomerulonephritisanty material consisting predominantly of cortical tissue. It is noted that it is especially the focally accentuated GN forms (FGN) in which the changes are frequently—and predominantly in the early stage—restricted to the cortico-medullary region and hence easily elude biopsy.
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Histology of Normal Kidney TissueNormal kidney tissue consists of unchanged nephrons (glomeruli and tubules), vessels and interstitium, reveals unchanged BM and mesangium upon examination with EM and is IF-negative.
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Histopathology of the Glomerulus Under High Power MagnificationFollowing low-power study, the next step involves the determination under high power LM and EM of the structural element(s) most intensely—and, presumably primarily—affected. Conventionally, the study sequence of structures in this process is glomeruli → tubules → vessels → interstitium.
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Histopathology of the Renal InterstitiumInterstitial changes are often treated in a cursory fashion in renal biopsy evaluation. This is to be discouraged since findings in the interstitium such as edema, fibrosis, and inflammatory infiltration often provide important information.
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