Titlebook: Regulatory Networks in Stem Cells; Vinagolu K. Rajasekhar,Mohan C. Vemuri Book 2009 Humana Press 2009 DNA.Expression.Telomere.anatomy.cell

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Asymmetric Behavior in Stem Cellscell divisions result in one daughter cell that is similar to the parent cell and, hence, necessarily allows for self-renewal of the stem cell phenotype, whereas the other daughter cell is a differentiated or committed cell type. In this chapter we will discuss the role of asymmetry in stem cell div

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Maintenance of Embryonic Stem Cell Pluripotency by Nanog-Mediated Dedifferentiation of Committed Meshe molecular and cellular mechanisms underlying ES cell pluripotency are, however, poorly understood. Here, we characterize a population of early mesoderm-committed (EM) progenitors that is generated from mouse ES cells by bone morphogenetic protein (BMP) stimulation. We further show that EM progeni

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Human Embryonic Stem Cells and Germ Cell Developmenthree primary germ layers. Evidence shows, however, that the cells of the ICM and derived ESCs are not identical. Expression of early germ cell–specific markers in undifferentiated ESCs and the ability of ESCs to differentiate into functional germ cells in vitro suggest that early germ cells and ESCs

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Genomic Stability in Stem Cellsts to genomic integrity. Reactive oxygen species, the most significant mutagens in stem cells, when elevated, activate the protective mechanisms blocking self-renewal and at the same time serve as a signal stimulating stem cell differentiation. Based on studies performed primarily on hematopoietic s

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Use of Zebrafish to Dissect Gene Programs Regulating Hematopoietic Stem Cellsw to maintain their own population so that the blood system always has the capacity to be reconstituted. This balance of HSCs producing more HSCs as well as differentiated blood cells is regulated by several extrinsic pathways. The . pathway has been shown to have a role in regulating embryonic stem

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