| 书目名称 | Regulation of Plasma Low Density Lipoprotein Levels Biopharmacological Regulation of Protein Phospho |
| 编辑 | W. R. Bartle,V. Braun,N. E. Winslade |
| 视频video | |
| 丛书名称 | Progress in Clinical Biochemistry and Medicine |
| 图书封面 |  |
| 描述 | Cholesterol is essential for normal cellular function. It is found in all cells of the body and is a major constituent of cell membranes. In addition, certain specialized tissues use cholesterol as the basic substrate for the synthesis of more complicated sterols such as bile acids and the steroid hormones. Like most lipids cholesterol has a very low solubility in water. Therefore, in order for these molecules to be transported be tween different organs of the body a series of lipid carriers known as lipoproteins has evolved. Over the last several years epidemiological evidence has accumulated suggest ing a strong relationship between the risk of atherosclerosis and high plasma concen trations of one of these lipoproteins, low density lipoprotein (LDL) 1). Thus, in popula tions with high plasma concentrations of LDL-cholesterol a correspondingly high incidence of vascular disease is seen. Since it has been demonstrated that reducing the steady-state plasma LDL-cholesterol concentration produces a proportional decrease in the risk of developing atherosclerosis 2), a major effort is now underway to develop safe and effective lipid lowering agents. In the past, these efforts have |
| 出版日期 | Conference proceedings 1988 |
| 关键词 | Calcium; Lipid; cell membrane; drug design; phosphorylation; protein; proteins; synthesis; tissue |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-72902-7 |
| isbn_softcover | 978-3-642-72904-1 |
| isbn_ebook | 978-3-642-72902-7Series ISSN 0177-8757 |
| issn_series | 0177-8757 |
| copyright | Springer-Verlag Berlin Heidelberg 1988 |
发表于 2025-3-21 18:16:34
