| 书目名称 | Regulation of Membrane Na+-K+ ATPase | | 编辑 | Sajal Chakraborti,Naranjan S Dhalla | | 视频video | | | 概述 | A comprehensive investigation into the ATPase regulation of Membrane Na+-K+ ATPase.Explores the specific inhibitors and molecular probes for membrane ATPases to improve the therapy of various diseases | | 丛书名称 | Advances in Biochemistry in Health and Disease | | 图书封面 |  | | 描述 | .Na.+.-K.+ .ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na.+.-K.+ .ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na.+.-K.+ .ATPase is either mediated by changes in intracellular Na.+. concentrations that directly affect the Na.+.-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na.+.-K.+ .ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na.+.-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. T | | 出版日期 | Book 2016 | | 关键词 | Membrane Na+-K+ ATPase; Cardiac Na+-K+ ATPase; Na+/K+-ATPase inhibitors; Na+-coupled cotransport; Na+-K+ | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-24750-2 | | isbn_softcover | 978-3-319-79672-7 | | isbn_ebook | 978-3-319-24750-2Series ISSN 2512-2142 Series E-ISSN 2512-2150 | | issn_series | 2512-2142 | | copyright | Springer International Publishing AG, part of Springer Nature 2016 |
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发表于 2025-3-21 18:00:30
