Titlebook: Regulation of Gene Expression; Gary H. Perdew,John P. Heuvel,Jeffrey M. Peters Book 2007 Humana Press 2007 Proteomics.RNA.Termination.Tran

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feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overvie

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Transcriptional Regulation of Gene Expressione events leading to transcriptional regulation are given in . and will be discussed in more detail. Further description of the molecular events associated with transcriptional regulation can be found elsewhere [1, 30].

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Overviewrious approaches available to determine how a treatment leads to altered protein function by a mechanism other than by changes in m. levels. This part examines the experimental approaches that can define the general mechanism(s) that lead to altered protein activity, as depicted in ..

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Proteomicshe global characterization of protein levels can a complete picture of possible changes evoked by a chemical treatment or altered cell phenotype be more fully established. After all, proteins usually are the end point of gene expression.

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Production of Transgenic Animalse will be used for mice that are generated by a combination of these Conditional null mice typically contain both a transgene that is usually used to regulate expression of Cre recombinase and a targeted allele containing flanking . sites that enable deletion of the gene product in a tissue- and time-specific manner.

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Book 2007nces. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental