Titlebook: Refractory Celiac Disease; Georgia Malamut,Nadine Cerf-Bensussan Book 2022 Springer Nature Switzerland AG 2022 gluten free diet.Refractory

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Laboratory Findings for the Diagnosis of Celiac Disease Related Complications,can be distinguished based on the immunophenotype of intraepithelial lymphocytes (IEL) and the immunogenetic status of TCRγ. While RCDI is a benign condition, RCDII is a clonal lymphoproliferation that can evolve towards an aggressive enteropathy-associated T-cell lymphoma (EATL). RCDII and EATL dis

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The Other Causes of Severe Enteropathy with Villous Atrophy Non-Responsive to a Gluten-Free Diet,aplotype testing, prior serologies, histology, family history, and the response both clinically and histologically to a gluten-free diet. If the original diagnosis is called into question, alternative causes of severe enteropathy with villous atrophy need to be considered. In this chapter we will fo

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Treatment of Refractory Celiac Disease,trophy. Based on the presence or absence of a clonal expansion of premalignant intra-epithelial lymphocytes in the small intestinal epithelium patients are recognized as either Type I or Type II refractory celiac disease (RCD). While the former generally has a relatively mild disease course, Type II

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Prognosis of Refractory Coeliac Disease: The Prognostic Scores,ly due to refractory CD (RCD) and other complications. Prognosis in RCD and other forms of complicated coeliac disease (CCD) is poor. In this chapter, we will first define the concepts of RCD and CCD. Then, we will outline and discuss predictors of both CCD and RCD to be evaluated at time of diagnos

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Enteropathy-Associated T-Cell Lymphoma,resence of refractory CD type II (RCD-II) is a prominent risk factor for developing EATL. EATL occurs most commonly in the jejunum, and is often diagnosed with intestinal perforation or obstruction. The prognosis of EATL is poor, with a five-year overall survival (OS) of 10–15%. Studies suggest that

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Introduction,e is currently the first line treatment. Nethertheless, recent advances in decephering pathogenic mechanisms of both types of RCD open new therapeutic strategies, to cure RCD and prevent Enteropathy Associated T cell Lymphoma.

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