书目名称 | Reelin Glycoprotein | 副标题 | Structure, Biology a | 编辑 | S. Hossein Fatemi (Professor of Psychiatry, Adjunc | 视频video | | 概述 | Provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies | 图书封面 |  | 描述 | .Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders. ..This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. . | 出版日期 | Book 2008 | 关键词 | Alzheimer; Oxytocin; alzheimer‘s disease; anatomy; autism; brain; cerebral cortex; cognition; cortex; protein | 版次 | 1 | doi | https://doi.org/10.1007/978-0-387-76761-1 | isbn_softcover | 978-1-4899-8695-5 | isbn_ebook | 978-0-387-76761-1 | copyright | Springer-Verlag New York 2008 |
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