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Titlebook: Recombinant Technology in Hemostasis and Thrombosis; Leon W. Hoyer,William N. Drohan Book 1991 Springer Science+Business Media New York 19

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发表于 2025-3-21 18:49:24 | 显示全部楼层 |阅读模式
书目名称Recombinant Technology in Hemostasis and Thrombosis
编辑Leon W. Hoyer,William N. Drohan
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图书封面Titlebook: Recombinant Technology in Hemostasis and Thrombosis;  Leon W. Hoyer,William N. Drohan Book 1991 Springer Science+Business Media New York 19
描述Recent progress in molecular biology has led to a rapid expansion of our understanding of the proteins that are essential for hemostasis and thrombosis. The goal of the XXI Annual Scientific Symposium of the American Red Cross was to provide a forum to explore and document the impact of recombinant DNA technology in this field. The speakers described the essential features of the genes responsible for key plasma proteins important in hemostasis, including procoagulant Factors VIII and IX and anticoagulant proteins, Antithrombin III and Protein C. They emphasized the advances in recombinant DNA technology that have led to the cloning of these genes. Careful examination of the gene sequence has then provided a clearer understanding of the structure of the encoded proteins, and has given additional insight into their functional domains and their interactions in hemostasis. At the same time, these advances have made it possible to better characterize hemostatic disorders. A large number of published studies have shown that the mutations affecting biological activity are clustered in areas that define functional domains. They have led to fundamental advances in our understanding of spec
出版日期Book 1991
关键词DNA; biology; genes; molecular biology; mutation; plasma; protein; proteins; thrombosis
版次1
doihttps://doi.org/10.1007/978-1-4615-3698-7
isbn_softcover978-1-4613-6644-7
isbn_ebook978-1-4615-3698-7
copyrightSpringer Science+Business Media New York 1991
The information of publication is updating

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发表于 2025-3-21 21:42:40 | 显示全部楼层
Molecular Defects in Hemophilia Brm whereas factor VIII is consumed. Marked genetic heterogeneity among different families with hemophilia B was suggested from comparison of factor IX antigen levels with clotting activities. In patients from different families, specific activities were usually distinctly different..
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Factor IX: Gene Structure and Protein Synthesis of the human factor IX gene, and discuss the various approaches to producing recombinant factor IX as a pharmaceutical. The molecular genetics of factor IX deficiency (hemophilia B) are discussed elsewhere in this book. The molecular biology and molecular genetics of blood coagulation have been reviewed recently..
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Antithrombin III Genetics, Structure and Functionchiometric ATIII-enzyme complexes form as a result of interactions between the reactive site of ATIII and the active site of the protease target.. The rate of complex formation increases substantially in the presence of heparan sulfate proteoglycans on the surface of the vascular endothelium .,. or after addition of heparin . or pharmaceutically..
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thrombosis. The goal of the XXI Annual Scientific Symposium of the American Red Cross was to provide a forum to explore and document the impact of recombinant DNA technology in this field. The speakers described the essential features of the genes responsible for key plasma proteins important in he
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Biosynthesis and Assembly of the Factor VIII-Von Willebrand Factor Complexcofactor in the intrinsic coagulation pathway (1, 2) whereas vWF is hemostatically important in the mediation of platelet-vessel wall interactions at sites of vascular injury (3, 4). In blood, factor VIII and vWF are not present as distinct proteins but rather circulate as a linked complex. Several
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Factor IX: Gene Structure and Protein Synthesisques, DNA fragments can be cloned and characterized at the molecular level. This in turn led to the discovery of intervening sequences in some eukaryotic genes, the identification of promoter elements, and to the production of recombinant proteins. As with many other fields, the field of thrombosis
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