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Titlebook: Receptors and Other Targets for Toxic Substances; Proceedings of the E Philip L. Chambers,Eszter Cholnoky,Claire M. Chamb Conference procee

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The Role of Receptors in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) ToxicityD and other chlorinated aromatic hydrocarbons with chlorine atoms in lateral positions (2,3,7,8-tetrachlorodibenzofuran, 3,3′,4,4′-tetrachloroazoxybenzene, 3,3′,4,4′(5,5′)-tetra(hexa)chlorobiphenyl), all bind to the receptor and show a similar pattern of toxicity, although there is a wide range in p
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Brain Glucocorticoid Receptors and Their Role in Behavioural Teratogenicity of Synthetic Glucocorticer was found in the cerebellum, the fastest growing part of perinatal brain. Dexamethasone (D) administration (0.04–3 mg · kg. s.c.) in 7-day-old rats induced dose-dependent depletion of brain cytosol GR with a 70% depletion after the smallest dose. Long-term effects of this GR mediated insult (D 1.
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Effect of Dithiocarbamate Fungicides and Thiurams on 3H-haloperidol Binding in Rat Brain the brain. Consequently, noradrenaline synthesis is decreased and dopamine tends to accumulate in the brain. It was decided to examine whether cerebral dopaminergic D.-receptor binding is affected by these agents after their short-term administration to rats. It appeared that ferbam, maneb, nabam,
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Mucosal Biotransformation of Toxins in the Gutswallowed respiratory mucus carrying part of the chemical loading of inspired air. The large surface area provides conditions for efficient absorption. The mucosa, however, forms an active barrier. There are several enzymes capable in oxidizing, reducing and hydrolysing xenobiotics as well as many e
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Intestinal Excretion of Toxic Substancescesses in the elimination of a highly lipophilic xenobiotic such as hexachlorobenzene (HCB) has been studied. It has been demonstrated that fecal (90%) rather than urinary (10%) excretion is the major route of elimination of HCB in most species. It has been shown also that the bile of HCB dosed anim
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Biochemical Changes of Intestinal Epithelial Cells Induced by Cytostatic Agents in Rats cytostatic agents. The symptoms of intestinal impairment: nausea, vomiting, diarrhea, ulceration, are well known both in clinical practice and in experimental chemotherapy. To obtain information about the biochemical nature of these side effects, a study was performed by investigating the influence
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