Titlebook: Receptor/Ligand Sorting Along the Endocytic Pathway; Jennifer J. Linderman,Douglas A. Lauffenburger Book 1989 Springer-Verlag Berlin Heide

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Book 1989 separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable p

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Introduction and Overview,immediate release to the environment, packaged into vesicles for later release to the environment upon the receipt of an appropriate stimulus, incorporated into the cell membrane or into organelle membranes, delivered to lysosomes to function there as enzymes, or delivered to other organelles. Molec

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Simple Kinetic Models of Sorting,n experimentally observed in several systems. In addition, this scheme does not allow for a variety of outcomes of the sorting process, as suggested by experimental data discussed later in this text (Chapters 5 and 6). Furthermore, it is not known whether the kinetics of ligand and receptor movement

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A Whole Cell Kinetic Model of the Endocytic Cycle: Focus on Sorting,e endosome. The most successful of these mechanisms, in terms of explaining the efficient recycling of receptors from the endosome back to the cell surface, suggested that receptors diffuse from the endosomal vesicles into tubules and are trapped there and that during this time ligand molecules equi