Titlebook: Receptor Tyrosine Kinases: Family and Subfamilies; Deric L. Wheeler,Yosef Yarden Book 2015 Springer International Publishing Switzerland 2

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The MET Receptor Family,gans, and types of cells, but is generally expressed in cells of epithelial origin. HGF/SF, on the other hand, is produced in stromal cells of mesenchymal origin. The MET receptor is synthesized as a 185 kDa single-chain precursor, which is proteolytically cleaved to yield a highly glycosylated extr