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Titlebook: Recent Advances in Neuropharmacology; H. Bönisch,K.-H. Graefe,E. Schömig Conference proceedings 1991 Springer-Verlag Wien 1991 ATP.Asparta

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The influence of the estrous cycle on the accumulation of 3H-noradrenaline in rat uterus and on effl with the labelled amine. Comparisons were made between uterine horns corresponding to each one of the 4 stages of the cycle, i.e., diestrus, proestrus, metestrus and estrus..Accumulation in diestrus reached the highest value, which was 1.64-fold higher than in estrus..An estimate of the original di
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PC12 cells as a window for the differentiation of neural crest into adrenergic nerve ending and adrechromaffin cells. This is revealed by the presence of monoamine oxidase (MAO) A and tyramine-released pool of catecholamines in PC12, resembling that in adrenergic neurones, and their absence in adrenal chromaffin cells. Indeed, chromaffin cells possess primarilly MAO-B activity. Like the observatio
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Clinical aspects on presynaptic noradrenaline metabolismosture or isoprenaline infusion. Blockade of neuronal uptake by desipramine abolished these plasma DOPEG responses and reduced plasma DOPEG per se. In essential hypertensives we found higher than normal plasma DOPEG levels at any given plasma NA. Evidence is provided that both the desipramine-sensit
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Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valprlsions (12 mA, 0.2 s stimulus duration) but desipramine (up to 40 mg/kg) remained ineffective. On the other hand, all drugs, amitriptiline (10mg/kg), desipramine (20mg/kg), and imipramine (20mg/kg) distinctly potentiated the protective efficacy of valproate against maximal electroshock, reducing its
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Involvement of catecholaminergic neurones of the nucleus of the solitary tract (NTS) in blood pressu revealed that increases in blood pressure elicited by the occlusion reduce the release rates of noradrenaline and adrenaline, while occlusion-induced decreases in blood pressure diminish the release rate of dopamine. These findings demonstrate that, in response to blood pressure changes elicited by
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Presynaptic modulation of neurotransmitter release by endogenous angiotensin II in brown adipose tiswas endogenously formed and subsequently released from ISF, immunoreactive All was measured in the superfusate from ISF slices. The concentration of All detected in the ISF superfusate was 4.51 pg/mg tissue wet wt/30ml collected over a 30-min period. In response to electrical field stimulation, All
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