Titlebook: Recent Advances in Mucosal Immunology; Part A: Cellular Int Jiri Mestecky,Jerry R. McGhee,Pearay L. Ogra Book 1987 The Editor(s) (if applic

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Regulatory T Cell Networks in the Secretory Immune Systems from the environment and represent the major bodily site of antigenic exposure and recognition. In the case of ingested antigens, there is selective uptake into the Peyer’s patches (PP), which are distinct aggregates of lymphoreticular nodules along the anti-mesenteric aspect of the gastrointestin

Finasteride

Novel Regulatory Mechanisms of IgA Synthesis: Respective Roles of Neuropeptides and Cells of the Antmmunoglobulin. There are several mechanisms that contribute to IgA making up such a large proportion of the antibody in intestinal secretions (reviewed in ref. 1) including: a high frequency of IgA B cell precursors in Peyer’s patches (2); T cells which facilitate an isotype switch from IgM to IgA (

Subdue

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Isotype-Specific Immunoglobulin Binding Factors of IgA and IgE in human as well as murine immune systems (1–7). IBFs for IgA (8–13) and IgE (14–18) are particularly important because of the clinical diseases involving the abnormalities of these systems. In selective IgA deficiency and IgA nephropathy, FcR/IBF for IgA is altered (19). In atopic as well as non-a

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T Cell Clones that Help IgA Responsesamina propria IgA plasma cell precursors in the mucosa-associated lymphoid tissue (MALT), especially the gut-associated lymphoid tissue (GALT). I GALT lymphoid nodules seem to provide a milieu in which commitment of B I cells to IgA production is especially favored. While many aspects of this I mili

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Antigen-Specific Helper T Cells in the Intestine: Origin and Migration humans (4,5) and mouse (6) and have been cloned from murine Peyer’s patches (PP) (7,8). The migration and distribution of these effector cells is crucial to a successful local response to antigen. Most studies of T cell migration have been undertaken with bulk populations responding to a wide range

FID

Limiting Dilution Analysis of Functional T Cells in the Gut Mucosahat virtually all intraepithelial lymphocytes (IEL) are of the T cell lineage because most of them are recognized by monoclonal antibodies specific for the T3 antigen complex associated with the T cell receptor (1,2). Functional data on these cells is, however, completely lacking. In rodents, the si

Affirm

Isotype-Specific Immunoregulation: T Contrasuppressor Cells Protect IgA Responses in Oral Tolerance role in allowing IgA response induction in the presence of T suppressor (Ts) cells which mediate systemic unresponsiveness (1). Continuous oral exposure to thymus-dependent (TD) antigen results in two seemingly-opposite responses, the induction of IgA responses at mucosal sites and systemic unrespo

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Regulatory T Cells in the Galteas the antigen driven differentiation of precursor cells is the central point of the B cell centered theories (1), others have suggested a crucial influence of T cells for the end stage differentiation of bone marrow derived cells into IgA secreting cells (2). Our own experiments with PP-deprived r