Titlebook: Ras Superfamily Small G Proteins: Biology and Mechanisms 2; Transport Alfred Wittinghofer Book 2014 Springer International Publishing Switz

反抗者

Ran in Nucleocytoplasmic Transportubunits. The nucleotide state of Ran provides a means by which the cytoplasmic and nucleoplasmic compartments are recognized as a consequence of RCC1, the Ran guanine nucleotide exchange factor (RanGEF), being located in the nucleus, whereas the Ran GTPase activating protein, RanGAP, is located in t

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ANA

Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Traffickand hydrolysis. The first function identified for Arf proteins was recruitment of cytosolic coat complexes to membranes to mediate vesicle formation. However, subsequent studies have uncovered additional functions, including roles in plasma membrane signalling pathways, cytoskeleton regulation, lipi

Afflict

不规则

ARF-Like (ARL) ProteinsFs and each other and are assumed to share basic mechanisms of regulation and a very incompletely documented degree of overlapping regulators. At least four ARLs were already present in the last eukaryotic common ancestor, along with one ARF, and these have been expanded to >20 members in mammals. W

FLING

Diverticulitis

Rag GTPasesbility to cell growth. Dysregulation of mTORC1 is implicated in a number of human diseases, including cancer and diabetes. In response to amino acid availability the Rag GTPases are regulated by the Ragulator and GATOR complexes, which are a guanine nucleotide exchange factor (GEF) and GTPase activa

GROWL

limber

Ran in Nucleocytoplasmic Transportget compartments, respectively. Generally the nucleocytoplasmic transport of macromolecules is mediated by transport factors of the karyopherin-β family that change their conformation depending on whether RanGTP is bound or not, and this conformational change in turn mediates the affinity of the transport factors for their cargoes.

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Book 2014 the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 th