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Titlebook: Radiotherapy, Surgery, and Immunotherapy; Frederick F. Becker Book 1977 Plenum Press, New York 1977 cancer.cell.dosimetry.immunotherapy.mo

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d other new techniques allowed the therapist to better focus upon the tumor and to improve the geometry of exposure. Thus, with each technical advance, the "reach" of radiotherapy was increased and damage to normal tissues was decreased. Inevitably, however, a limit was reached, a point at which clinicians an978-1-4684-2741-7978-1-4684-2739-4
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Hypoxic Cell Sensitizers for Radiotherapyue potentiation is, however, difficult to characterize since, depending on the criteria of measurement, the complex nature of dose-response curves can sometimes indicate apparent potentiation when, in reality, the drug and radiation treatments are giving a purely additive affect in terms of cell killing.
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Present Status of Radiation Therapy of Cancer: An Overvieweatment of skin and other superficial neoplasms were so unprecedented that they generated the unrealistic hope that a miraculous cure for cancer had finally been discovered. This naive view was soon followed by an equally unwarranted wave of disillusionment and pessimism when tumor recurrences and injuries to normal tissues began to appear.
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Radiation Effects on Normal Tissuesf localized disease. Systemic chemotherapy is the main method of treatment for widely disseminated cancer, but whole-body or regional irradiation is sometimes used prophylactically, for example, in leukemia (brain) or osteosarcoma (lungs). Hyperthermia is also being used more extensively.
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Effects of Radiation on Animal Tumor Modelsmit the observations that can be made and the phenomena that can be studied quantitatively. As a result, most of the available data defining the effects of radiation on tumors have been obtained from experiments with tumors in experimental animals or with experimental tumor models ..
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