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Titlebook: Radioprotection; Chemical Compounds-B A. Locker,K. Flemming Book 1977 Springer Basel AG 1977 biological.biology.compound.DNA.DNA repair.env

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Some Ideas Concerning the Mode of Action of Radioprotective Agents,fect on the central nervous system [4]. A participation of biological and pharmacological components has also been discussed for thiols [5] and other substances (fatty compounds, estrogens, lipopolysaccharides) [6]. In this connection, the question of an effect of these substances on regulating and
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Some General Aspects of Radioprotection (a Summary),cts, we refer (1) to paradoxical reactions that hint strongly at the underlying mechanism of action, (2) to the temporal dependence of protection and (3) to the fact that radioprotection must of necessity be viewed in connection with systemic relationships.
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General Patterns of DNA Repair and Their Possible Significance as Necessary Protection from Environometrical and statistical factors of radiation and to minimize the importance of biological modifications of injury. Also more recently [2, 3] efforts have been continued to fit radiation response data through geometrical parameters.
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Protection by Hypoxia and the Effect of Low Oxygen Tensions on Radiosensitivity,ged by a given dose of X- or .-rays than when well supplied with oxygen. Mottram, for example, in the mid 30’s suggested that the skin could be protected in radiotherapy by limiting the blood supply by pressure or other means during irradiation [1–3]. In 1942, Lacassagne demonstrated a marked protec
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Radioprotection by Radiosensitizers,on. In considering the multitarget single-hit model, cellular sensitivity can be modified in the sense of a change in the energy per lethal event and/or in the sense of a change in the amount of accumulated damage, i.e. . as well as .. can change. As has recently been discussed in detail [1], increa
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Systemic Factors Affecting the Radioprotective Effectiveness of Phosphorothioates,tion in vivo, but it is somewhat of an oversimplification to assume that their relative effectiveness in vivo is solely, or even primarily, a reflection of their respective abilities to participate in these physico-chemical interactions. Alternatively, we suggest that the major determinant of in viv
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