Titlebook: Radionuclide Imaging in Drug Research; Clive George Wilson,John G. Hardy,S. S. Davis Book 1982 C.G. Wilson, J.G. Hardy, M. Frier and S.S.

judicial

Choice of Radionuclides for Scintigraphy,s places some constraint on the type of substance to be labelled, but more importantly on the radionuclide to be employed as the radiolabel. The agents are normally administered at low concentrations and low frequency (often only once) and the radionuclides commonly employed in scintigraphy are eith

带来

Obstacle

Quality Control of Radiopharmaceuticals,patient. Conventionally, radiopharmaceutical agents are products in which a radionuclide label is formulated in such a way as to cause it to localise in some organ or lesion. Once localised, the externally detectable radiation may be displayed to produce clinically useful diagnostic information, and

皮萨

Radiopharmaceutical Distribution Studies in the Rat,rmaceuticals are diagnostic agents and, in general, they do not produce any pharmacological effects. Intravenous injection is the most widely used method of administration. Radiopharmaceuticals are available which remain in the circulation, collect in various tissues, or concentrate in specific orga

变化

Studies of Radiolabelled Preparations in the Rabbit,s influenced by many factors including the rate of release of drug from the formulation, the metabolism of the drug, the vascularity of the target tissue and the uptake of drug or active metabolite by the receptors.

Enervate

The Utilisation of Short-Lived Radionuclides in the Assessment of Formulation and in Vivo Dispositidrugs. It includes examples obtained in the author’s laboratory and does not represent an exhaustive account of the current literature on the subject. Tablet disintegration as a function of gastric emptying and formulation is discussed. It has been shown that, by labelling one batch of tablets with

N斯巴达人

Gastrointestinal Transit of Gamma-Emitting Radionuclide Labelled Preparations,ma camera or scintiscanning equipment (Alpsten et al. 1976, Casey et al. 1976, Hunter et al. 1980). The information most readily obtained from such studies is the behaviour of the dosage forms in the stomach and the subsequent emptying into the duodenum. Once in the small intestine, the position of

苍白

MAPLE

Immunization

In Vivo Radioimmunodetection of Cancer,loped antisera from a human oesteogenic sarcoma in donkey and in dogs. These investigators found that their sera were effective in reducing the size of two tumours, a carcinoma of the stomach and a fibro-sarcoma. In a subsequent article these authors described 50 cases that had been treated by antib