| 书目名称 | Radiation Oncology Advances |
| 编辑 | Søren M. Bentzen,Paul M. Harari,Minesh P. Mehta |
| 视频video | |
| 概述 | An up-to-date comprehensive overview of new developments in radiation oncology by leading experts in the field.Includes advances in treatment planning and delivery, in biological targeted therapies co |
| 丛书名称 | Cancer Treatment and Research |
| 图书封面 |  |
| 描述 | from combining radiation with a molecular targeted agent – namely cetuximab, a recombinant mouse/human chimeric monoclonal antibody against the Epidermal Growth Factor (EGF) receptor [4] Astsaturov, Cohen and Harari present a more indepth review of the biology of the EGF Receptor and its signaling pathway in Chap. 7 as a potential target in combination with fractionated radiotherap y for head and neck squamous cell carcinoma (HNSCC). A flurry of agents are under de velopment for targeting EGFR and in March 2006, the US Food and Drugs Administration approved cetuximab combined with radiation as a primary treatment option for patients with loco-regionally advanced HNSCC in whom chemoradiation therapy is deemed not to be an option. While blocking the EGF pathway during fractionated radiotherapy may seem an obvious strategy [5], the rationale for combining antiangiogenic and antivascular targeting agents with radiation may be less intuitive. However, recent research shows that there are several reasons why this could result in a therapeutic gain in practice. Chapter 8 is a review of this rapidly expanding field by Citrin and Camphausen. Targeted agents combined with radiation may offer |
| 出版日期 | Book 2008 |
| 关键词 | brachytherapy; cancer; cell; imaging; magnetic resonance imaging (MRI); molecular biology; molecular imagi |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-0-387-36744-6 |
| isbn_softcover | 978-1-4419-4221-0 |
| isbn_ebook | 978-0-387-36744-6Series ISSN 0927-3042 Series E-ISSN 2509-8497 |
| issn_series | 0927-3042 |
| copyright | Springer-Verlag US 2008 |
发表于 2025-3-21 19:24:31
