Titlebook: RNA Towards Medicine; Volker Erdmann,Jan Barciszewski,Jürgen Brosius Book 2006 Springer-Verlag Berlin Heidelberg 2006 DNA.RNAi.Termination

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Arthritis

Regulatory RNAs in Mammals,ell-known classes of RNAs that take part in the transmission of genetic information from DNA to proteins, a new highly heterogeneous group of RNA molecules has emerged. The regulatory nonprotein-coding RNAs (npcRNAs) have been shown to be involved in modulation of gene expression on both the transcr

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Aminoglycoside Interactions with RNAs and Nucleases,des interact and interfere with the function of several noncoding RNAs, among which ribosomal RNAs (rRNAs) are the best studied. Aminoglycosides are also known to interact with proteins such as ribonucleases. Here we review our current understanding of the interaction between aminoglycosides and RNA

mucous-membrane

压迫

Antiviral Applications of RNAi,get gene. This down-regulation has been thought to predominantly function at the level of the messenger (m)RNA, post-transcriptional gene silencing (PTGS). Recently, the discovery that siRNAs can function to suppress a gene’s expression at the level of transcription, i.e., transcriptional gene silen

客观

RNA Interference: Its Use as Antiviral Therapy,against viruses and transposons. RNAi was first observed in plants in the form of a mysterious immune response to viral pathogens. But RNAi is more than just a response to exogenous genetic material. Small RNAs termed microRNA (miRNA) regulate cellular gene expression programs to control diverse ste

ALE

Gene Silencing of Virus Replication by RNA Interference,RNAs are widely used for assessing gene function in cultured mammalian cells or early developing vertebrate embryos. They are also promising reagents for developing gene-specific therapeutics. The specific inhibition of viral replication is particularly well suited to RNAi, as several stages of the

expdient

Progress in the Development of Nucleic Acid Therapeutics,ly less toxic than conventional therapies due its specificity. Over the years, many strategies have been proposed for silencing gene expression in a gene-specific manner. Three major approaches are antisense oligonucleotides (AS-ONs), ribozymes/DNAzymes, and RNA interference (RNAi). In this brief re

小木槌

Screening and Determination of Gene Function Using Randomized Ribozyme and siRNA Libraries,vided abundant sequence information, but functions of long stretches of these genomes remain to be determined. RNA-based technologies hold promise as tools that allow us to identify the specific functions of portions of these genomes. In particular, catalytic RNAs, known also as ribozymes, can be en