Titlebook: RNA Exosome; Torben Heick Jensen Book 2010 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Bu

Antecedent

muscle-fibers

EVICT

The Human Exosome and Disease,we will describe the identification of the PM/Scl autoantigen from a historical perspective, discuss our current knowledge on the occurrence of autoantibodies to exosome components in autoimmune diseases and end with the data that connect the exosome with cancer.

公猪

Catalytic Properties of the Eukaryotic Exosome,onucleolytic one. Rrp6 proteins are distributive exonucleases. This chapter will review the current knowledge about the catalytic properties of theses nucleases and their interplay within the exosome holocomplex.

异教徒

exacerbate

FIS

Structural Components and Architectures of RNA Exosomes,ubstrates by the RNA exosome. This chapter will focus on the structural organization of eukaryotic exosomes and their evolutionary cousins in bacteria and archaea with an emphasis on mechanistic details related to substrate recognition and to 3′ to 5′ phosphorolytic exoribonucleolytic activities of

的事物

The Archaeal Exosome, alternating Rrp41 and Rrp42 polypeptides, arranged in a hexameric ring. A flexible RNA binding cap composed of the evolutionarily conserved proteins Rrp4 and/or Csl4 is bound at the top of the ring and seems to be involved in recruitment of specific substrates and their unwinding. Additionally, the

果核

The Exosomes of Trypanosomes and Other Protists,omain proteins. In animals and yeast, six different, but related subunits form the RNase PH-like core, but these lack enzyme activity; there are three different Si-domain proteins and enzyme activity is provided by the endo/exonuc lease Rrp44 or—mainly in the nuclear exosome—the Rnase D enzyme Rrp6.

ANNUL

,The Exosome and 3′–5′ RNA Degradation in Plants,plex, which associates with active ribonucleases, RNA binding proteins, helicases and additional co-factors. While yeast and human exosome core complexes are catalytically inactive, the plant core complex has probably retained a phosphorolytic activity. Intriguingly, the down-regulation of individua