Titlebook: Quantitative Structure-Activity Relationships; Proceedings of the C Miloň Tichý Conference proceedings 1976 Springer Basel AG 1976 Biologie

钳子

Use of Structure-Activity Relationships to Estimate Toxicity of Inorganic Cationsother by different substituents in the basic skeleton of the molecule were found. If the molecule of a substance is considered as it enters the organism leaving aside the metabolic changes of the substance before its interaction with the receptor, it is always the whole molecule that is the matter.

intangibility

Neutral-Spine

Substructural Analysis in Drug Designethods is their weakness in accommodating data represented by inactive compounds. In essence, existing structure-activity correlation methodologies are useful only for optimizing a previously recognized “lead” structure and not in generating new “leads”.

bourgeois

neologism

Dissolution Rate as a Parameter in Structure-Activity Studiesese factors, partition coefficient has emerged as perhaps the most significant, and it has often been shown that the variation of biological activity within a series of compounds can be accounted for largely by variation in partition coefficient.

micronutrients

Relationship Between ,, Values from Paper Chromatography and Partition Coefficients of Dissociable C1949, Martin deduced a linear correlation between logarithms of partition coefficients and .. values obtained from partition chromatography. We made use of this correlation in groups of cinnamic, β-aryl-.-butyric, and α-arylpropionic acids. Their structures are shown in Fig. 1.

赔偿

Correlation Between Physico-Chemical Properties of Chemical Compounds and Indices of their Toxic Actand biological, in particular toxic, action on the other is more than one hundred years old. Prominent scientists of the last and the present centuries took part in the development of this field of science and now considerable experimental material and some theoretical conceptions are available.

一加就喷出

Structure-Activity Correlations in a Homologous Series of 2-Substituted Isonicotinic Acid Hydrazidestinic acid hydrazide (INH) has been one of the most effective drugs in tuberculosis therapy since 1952 when its antibacterial activity against . was discovered [1, 2]. Numerous derivatives have been prepared since then, however, none of them possessed a higher activity than INH itself.

MELON

Hansch Analysis in a Series of Substances with Antifungal ActivityFor some time we have been studying substances of the following type, that exhibit an interesting antifungal activity:

bacteria

The Prediction of New Biologically Active Compounds Using Physicochemical Properties-Activity RelatiThis paper describes a case in which the physicochemical-activity relations method, based on the procedure of Hansch [1], was used in a real-life industrial situation to investigate a series of biologically active compounds and to predict new compounds which could be expected to have high activity.