Titlebook: Quantitative Methods in Pharmaceutical Research and Development; Concepts and Applica Olga V. Marchenko,Natallia V. Katenka Book 2020 Sprin

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Modern Analytic Techniques for Predictive Modeling of Clinical Trial Operations,ring optimal design accounting for enrollment and follow-up stages; detection unusual event’s patterns in event-driven trials. For modeling more complicated hierarchic operational processes, a new methodology using evolving stochastic processes is also proposed. Some applications are considered.

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Biostatistics in Clinical Trials,iostatistics have greatly improved. Biostatisticians are not only responsible for the quantitative properties of clinical trial designs and for analyzing data from clinical trials, they are also respected partners of the clinical teams contributing to strategic discussions and helping solve day-to-d

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Causal Inference in Pharmacoepidemiology,y research, study designs lack randomized interventions that allow for causal inference. Yet, there are important and meaningful causal questions to address for non-randomized interventions. In this chapter, we provide an overview of the causal inference paradigm, review current methodology, and dis