| 书目名称 | Quantitative Aspects of Allosteric Mechanisms | | 编辑 | Alexander Levitzki | | 视频video | | | 丛书名称 | Molecular Biology, Biochemistry and Biophysics‘ Molekularbiologie, Biochemie und Biophysik | | 图书封面 |  | | 描述 | The aim of this monograph is to summarize the essential features which characterize the behavior of regulatory systems. Firstly we discuss the laws which govern ligand binding in thermodynamic terms. The basic cooperative and allosteric phenomena are des cribed in thermodynamic terms without assuming any particular mo del. Then the molecular models developed by Monod, Wyman and Changeux and by Koshland, Nemethy and Filmer are presented in detail. Special emphasis has been given to the analysis of the Hill coefficient and its meaning both in thermodynamic terms and in terms of the two allosteric models: the concerted model of Monod, Wyman and Changeux and the sequential model of Koshland, Nemethy and Filmer. Special types of cooperativities are dis cussed in some detail namely, cooperativity stemming from ligand coupled protein association or dissociation, negative cooperati vity and half-of-the-sites reactivity. A slightly extended space was devoted to the discussion of negative cooperativity and half of-the-sites reactivity, since the existence of these phenomena and their possible biological importance is less of a common knowledge than positive cooperativity. This monograp | | 出版日期 | Book 1978 | | 关键词 | Allosterie; Cooperativity; Enzym; Kooperativität (Biochem; ); Regulation; behavior; biology; enzyme; enzymes; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-81231-6 | | isbn_softcover | 978-3-642-81233-0 | | isbn_ebook | 978-3-642-81231-6Series ISSN 0077-0221 | | issn_series | 0077-0221 | | copyright | Springer-Verlag Berlin · Heidelberg 1978 |
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发表于 2025-3-21 17:49:49
