| 书目名称 | Purine Metabolism in Man—II |
| 副标题 | Regulation of Pathwa |
| 编辑 | Mathias M. Müller,Erich Kaiser,J. Edwin Seegmiller |
| 视频video | |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate in such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today‘s clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyltransferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-produc |
| 出版日期 | Book 1977 |
| 关键词 | Fructose; Glutamin; Lipid; NADP; Nucleotide; Purine; Pyrimidine; carbohydrates; enzyme; enzymes; metabolism; mu |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4613-4223-6 |
| isbn_softcover | 978-1-4613-4225-0 |
| isbn_ebook | 978-1-4613-4223-6Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 18:24:50
