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Titlebook: Purification of Peptides in High-Complexity Arrays; A New Method for the Christopher Schirwitz Book 2013 Springer International Publishing

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书目名称Purification of Peptides in High-Complexity Arrays
副标题A New Method for the
编辑Christopher Schirwitz
视频video
概述Nominated as an outstanding Ph.D. thesis by the Institute of Applied Physical Chemistry, University of Heidelberg, and the German Cancer Research Center (DKFZ) Heidelberg, Germany.Outlines an improvem
丛书名称Springer Theses
图书封面Titlebook: Purification of Peptides in High-Complexity Arrays; A New Method for the Christopher Schirwitz Book 2013 Springer International Publishing
描述Christopher Schirwitz‘s thesis focuses on improving the quality of in situ synthesized high-complexity peptide micro arrays. Micro arrays containing proteins or small protein fragments in the form of peptides have become of great interest in proteomic research. .With the help of these microarrays a large number of potential target molecules can be screened for interaction with a probe in a short timeframe. However, protein and peptide .micro arrays are still lagging behind oligonucleotide arrays in terms of density, quality and manufacturing costs. A new approach developed at the German Cancer Research .Center (DKFZ) has improved the synthesis of high-density peptide arrays. The current technology is capable of producing arrays with up to 40,000 different peptides per square cm by means of micro particle-based solid phase peptide synthesis. However, in situ synthesis approaches bear a conceptual disadvantage: The quality of the peptides is dependent on the efficiency of the synthesis so that peptide fragments are present in the resulting array among the desired full-length peptides. In peptide-protein interaction studies such peptide fragments. The central achievement of this thesi
出版日期Book 2013
关键词Cleavable Linkers; Coupling Peptides; Ellipsometry; Immunostaining; Peptide Arrays; Peptide Synthesis; Pep
版次1
doihttps://doi.org/10.1007/978-3-319-00807-3
isbn_softcover978-3-319-34559-8
isbn_ebook978-3-319-00807-3Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer International Publishing Switzerland 2013
The information of publication is updating

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