| 书目名称 | Protein Kinase C in Cancer Signaling and Therapy | | 编辑 | Marcelo G. Kazanietz | | 视频video | | | 概述 | Focuses specifically on PKC signaling at a mechanistic level in the context of cancer.The first to present in a very detailed manner the implication of PKC isozymes in different types of cancers.There | | 丛书名称 | Current Cancer Research | | 图书封面 |  | | 描述 | .Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable...This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in th | | 出版日期 | Book 2010 | | 关键词 | DNA; apoptosis; cancer; cancer research; cancer therapy; carcinogenesis; carcinoma; cell; inflammation; melan | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60761-543-9 | | isbn_softcover | 978-1-61779-691-3 | | isbn_ebook | 978-1-60761-543-9Series ISSN 2199-2584 Series E-ISSN 2199-2592 | | issn_series | 2199-2584 | | copyright | Springer Science+Business Media, LLC 2010 |
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发表于 2025-3-21 16:38:42
