| 书目名称 | Protein Instability at Interfaces During Drug Product Development | | 副标题 | Fundamental Understa | | 编辑 | Jinjiang Li,Mary E. Krause,Raymond Tu | | 视频video | | | 概述 | Provides fundamental understanding of the behavior of proteins at interfaces.Covers examples of protein interfacial activity in early development through product manufacture.Includes an overview of an | | 丛书名称 | AAPS Advances in the Pharmaceutical Sciences Series | | 图书封面 |  | | 描述 | . .Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in thesurface science, pharmaceutical, and medicinal chemistry areas... .. . | | 出版日期 | Book 2021 | | 关键词 | Protein purification; drug delivery of biologics; drug storage condiditons; protein interfacial stress; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-57177-1 | | isbn_softcover | 978-3-030-57179-5 | | isbn_ebook | 978-3-030-57177-1Series ISSN 2210-7371 Series E-ISSN 2210-738X | | issn_series | 2210-7371 | | copyright | American Association of Pharmaceutical Scientists 2021 |
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发表于 2025-3-21 17:12:42
