| 书目名称 | Protein Allostery in Drug Discovery | | 编辑 | Jian Zhang,Ruth Nussinov | | 视频video | | | 概述 | Focuses on protein allostery in drug discovery.Draws together the study of protein structure/function and the study of allostery.Contributed by experts in this field | | 丛书名称 | Advances in Experimental Medicine and Biology | | 图书封面 |  | | 描述 | .The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for sci | | 出版日期 | Book 2019 | | 关键词 | Allosteric Drug Discovery; Allosteric Modulator; Allosteric Regulation; Allosteric Site; Protein Alloste | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-13-8719-7 | | isbn_softcover | 978-981-13-8721-0 | | isbn_ebook | 978-981-13-8719-7Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | Springer Nature Singapore Pte Ltd. 2019 |
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发表于 2025-3-21 16:38:07
