| 书目名称 | Proteases: Structure and Function | | 编辑 | Klaudia Brix,Walter Stöcker | | 视频video | | | 概述 | Written by designated experts in the field defined models are described.Ensures a better understanding of biological significance of proteinases.Clearly shows the diversity and networking of enzymes.I | | 图书封面 |  | | 描述 | Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the d | | 出版日期 | Book 2013 | | 关键词 | enzyme; proteinase; proteinase function; proteinase structure; Protein Structure | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-7091-0885-7 | | isbn_softcover | 978-3-7091-1939-6 | | isbn_ebook | 978-3-7091-0885-7 | | copyright | Springer-Verlag Wien 2013 |
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发表于 2025-3-21 18:17:16
