| 书目名称 | Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy | | 副标题 | Molecular Mechanisms | | 编辑 | Andrea Bonetti,Roberto Leone,Stephen B. Howell | | 视频video | | | 概述 | The papers in this volume have been presented at the X International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy held in Verona, Italy, from November 30th to December 3rd 2007. | | 丛书名称 | Cancer Drug Discovery and Development | | 图书封面 |  | | 描述 | Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was joint | | 出版日期 | Book 2009 | | 关键词 | Antiproliferative; Cancer Chemotherapy; Carcinom; Cellular Transport; DACH-platinum; DNA repair; Heavy Met | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60327-459-3 | | isbn_softcover | 978-1-4939-5710-1 | | isbn_ebook | 978-1-60327-459-3Series ISSN 2196-9906 Series E-ISSN 2196-9914 | | issn_series | 2196-9906 | | copyright | Humana Press 2009 |
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发表于 2025-3-21 20:07:04
