| 书目名称 | Planning and Analyzing Clinical Trials with Composite Endpoints |
| 编辑 | Geraldine Rauch,Svenja Schüler,Meinhard Kieser |
| 视频video | |
| 概述 | Discusses methods for planning and evaluating clinical trials with a composite primary endpoint.Offers software codes for the implementation of methods.Summarizes current medical and methodology guide |
| 丛书名称 | Springer Series in Pharmaceutical Statistics |
| 图书封面 |  |
| 描述 | .This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful. . .The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes required for fast and easy implementation are provided. The book also discusses all the methods in the context of relevant guidelines related to the topic. To benefit most from |
| 出版日期 | Book 2017 |
| 关键词 | 62L05, 62P10; composite endpoints; clinical trials; sample size calculation; sequential designs; multiple |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-73770-6 |
| isbn_softcover | 978-3-030-08855-2 |
| isbn_ebook | 978-3-319-73770-6Series ISSN 2366-8695 Series E-ISSN 2366-8709 |
| issn_series | 2366-8695 |
| copyright | Springer International Publishing AG, part of Springer Nature 2017 |
发表于 2025-3-21 17:18:38
