书目名称 | Phosphoinositide 3-kinase in Health and Disease |
副标题 | Volume 2 |
编辑 | Christian Rommel,Bart Vanhaesebroeck,Peter K. Vogt |
视频video | |
概述 | From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in c |
丛书名称 | Current Topics in Microbiology and Immunology |
图书封面 |  |
描述 | PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target |
出版日期 | Book 2011 |
关键词 | PDK1; PIK3; TOR kinase domain inhibitor; haematological malignancies; malignant glioma; oncogenesis; oncop |
版次 | 1 |
doi | https://doi.org/10.1007/978-3-642-14816-3 |
isbn_softcover | 978-3-642-26530-3 |
isbn_ebook | 978-3-642-14816-3Series ISSN 0070-217X Series E-ISSN 2196-9965 |
issn_series | 0070-217X |
copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |