| 书目名称 | Pharmacology of the WNT Signaling System | | 编辑 | Gunnar Schulte,Pawel Kozielewicz | | 视频video | | | 概述 | Elaborates on molecular mechanisms of signal transduction in the WNT signaling system.Provides a state-of-the-art summary of the present concepts of targeting WNT signaling for therapy.Casts new light | | 丛书名称 | Handbook of Experimental Pharmacology | | 图书封面 |  | | 描述 | This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made t | | 出版日期 | Book 2021 | | 关键词 | WNT; Frizzled; cancer; fibrosis; therapy; pharmacology; casein kinase; porcupine inhibitor | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-85499-7 | | isbn_softcover | 978-3-030-85501-7 | | isbn_ebook | 978-3-030-85499-7Series ISSN 0171-2004 Series E-ISSN 1865-0325 | | issn_series | 0171-2004 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 19:13:51
