| 书目名称 | Pharmacology of Drug Stereoisomers |
| 编辑 | Alexander A. Spasov,Igor N. Iezhitsa,Renu Agarwal |
| 视频video | |
| 概述 | Outlines most updated state of knowledge on drug chirality.Explains how chirality affects the drug activity and influences their clinical applications in several areas.Presents chemical structures and |
| 丛书名称 | Progress in Drug Research |
| 图书封面 |  |
| 描述 | .The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the sta |
| 出版日期 | Book 2022 |
| 关键词 | chirality; pharmacology; stereochemistry; stereopharmacokinetics; stereopharmacodynamics; toxicity |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-19-2320-3 |
| isbn_softcover | 978-981-19-2322-7 |
| isbn_ebook | 978-981-19-2320-3Series ISSN 0071-786X Series E-ISSN 2297-4555 |
| issn_series | 0071-786X |
| copyright | Springer Nature Singapore Pte Ltd. 2022 |
发表于 2025-3-21 16:39:02
