| 书目名称 | Peptide Transport and Delivery into the Central Nervous System | | 编辑 | Laszlo Prokai,Katalin Prokai-Tatrai | | 视频video | | | 概述 | Discusses strategies to overcome the blood-brain-barrier.Comparative evaluation of the present state of drug delivery strategies.Biological carriers, prodrug and chemical delivery/targeting strategies | | 丛书名称 | Progress in Drug Research | | 图书封面 |  | | 描述 | .Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and b | | 出版日期 | Book 2003 | | 关键词 | CNS; Nervous System; blood-brain-barrier; brain; central nervous system; diseases; drug; drug delivery; drug | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-0348-8049-7 | | isbn_softcover | 978-3-0348-9420-3 | | isbn_ebook | 978-3-0348-8049-7Series ISSN 0071-786X Series E-ISSN 2297-4555 | | issn_series | 0071-786X | | copyright | Springer Basel AG 2003 |
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发表于 2025-3-21 19:02:01
