| 书目名称 | Pathways for Cytolysis | | 编辑 | Gillian M. Griffiths,Jürg Tschopp | | 视频video | | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A closer look, however, reveals the complex mechanisms underlying this task. Killer cells are able to specifically recognize altered or infected cells. A transient contract with target cells has to be established to allow the delivery of lethal molecules or signals. The killer cell then disengages from the damaged cell and moves away to kill other target cells. After the eradication of the target cells, the number or activity of activated killer cells has to be reduced to avoid nonspecific killing of innocent cells. In 1992, Herman Eisen concluded, in his introductory remarks in the most recent volume on lymphocyte cytotoxicity (EISEN 1993): "Given the immense amount of effort made in the past decade to understand these (lytic) mechanisms, it seems surprising that a consensus about the principal mechanisms has not been reached." Since that time, advances made in the field of cell-mediated cytolysis are so significant that our knowledge regarding the lytic mechanisms has been considerably augmented. Much of this is due to studies with transfectants and mutants-either naturally occurring | | 出版日期 | Book 1995 | | 关键词 | Granzymes; Perforin; Zellerkrankung; apoptosis; cancer; cell; cell cycle; cytotoxicity; enzyme; gene; gene tra | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-79414-8 | | isbn_softcover | 978-3-642-79416-2 | | isbn_ebook | 978-3-642-79414-8Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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发表于 2025-3-21 17:40:05
