Titlebook: Paroxysmal Nocturnal Hemoglobinuria; From Bench to Bedsid Yuzuru Kanakura,Taroh Kinoshita,Jun-ichi Nishimura Book 2017 Springer Japan KK 20

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Epidemiology in PNH: The PNH Global Registryf PNH. Over the past 25 years, novel diagnostics and therapeutic agents have refined the definition of the disease and improved clinical outcomes. These achievements have set the stage for developing an International PNH Registry that is an ongoing worldwide, noninterventional study collecting safet

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Haemolysis in PNH: Depletion of Nitric Oxided lysis resulting in free haemoglobin release. Nitric oxide induces a coordinated programme of cellular events that promote blood flow and maintain smooth muscle tone. Nitric oxide reacts with haem groups quickly and irreversibly. In situations of intravascular haemolysis, as seen in PNH, nitric oxi