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Titlebook: Parkinson’s Disease and Movement Disorders; Diagnosis and Treatm Charles H. Adler (Consultant and Co-Director, Asso Book 2000 Springer Scie

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发表于 2025-3-25 07:01:12 | 显示全部楼层
Initial Symptomatic Treatment of Parkinson’s Diseasesome to the patient. For example, someone in the public eye might be quite disabled by parkinsonian tremor that might not bother others. Clearly, however, persons curtailing their activities because of parkinsonism should be treated with adequate medications and doses.
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Surgical Treatment or Parkinson’s Diseaseergence of techniques that favor protection or replacement of at-risk cell populations. Surgical treatment of PD has a checkered history. Nonetheless, patients continue to be attracted to surgical strategies that are glamorized by clinician proponents and the media.
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Progressive Supranuclear Palsyways. In PSP, additional basal ganglia nuclei are involved, as are other subcortical areas and sometimes the cortex (especially frontal). The clinical hallmarks of PSP—down-gaze paresis, falling early in the course, and other features noted below—reflect this extranigral pathologic involvement.
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What Is Parkinson’s Disease? Neuropathology, Neurochemistry, and Pathophysiologypecific pattern of biochemical pathology, and an unknown cause. Its name immortalizes Dr. James Parkinson, the British physician whose classic 1817 monograph, ., is unrivaled as a lucid and timeless description of the cardinal symptoms and signs of what is now recognized as one of the most common ne
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Clinical Features of Parkinson’s Diseaseve become widely known to physicians and even to the general public. Statistically speaking, most patients who present with resting tremor, slowing of movement, gait difficulty, and limb rigidity have idiopathic PD. When a typical resting tremor appears in the elderly, patients and their relatives m
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Parkinson’s Disease: Etiologic Considerationsompacta neurons within the midbrain is pronounced in patients with PD. These dopaminergic neurons project to the striatum, and loss of striatal dopamine is responsible for most of the motor deficits of PD.
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Medication Strategies for Slowing the Progression of Parkinson’s Diseasedisorder. It was soon recognized, however, that the disease continues to progress despite levodopa treatment. This progression is not rapid but occurs over many years. Potentially, there are three avenues of progression, and they occur to variable degrees (Table 7-1). In the first are levodopa treat
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