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Titlebook: Parkinsonism and the Environment; Nikolay M. Filipov Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Emerging Contaminants as Contributors to Parkinsonism: Heterocyclic Amines,to be directly caused by genetic factors. Extensive research has focused on environmental factors that may influence risk. Metals, pesticides and other occupational and environmental exposures have received significant attention. However, for most individuals, high-dose exposures from these exposure
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PKC-Delta Is a Major Molecular Target for Diverse Dopaminergic Toxicants: Implications for Mechanistic and Translational Neurotoxicology,ignaling cascades. The tripartite mode of PKCδ activation including membrane translocation, tyrosine phosphorylation and proteolysis dictates its diverse cellular functions. Activation of this kinase by diverse apoptotic and inflammatory stimuli leads to its translocation to distinct cellular compar
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The Use and Predictability of , as an Alternative and Complementary Model in Neurotoxicological Studies: Focus on the Dopaminergic System,ile can be observed. Neurotoxicology studies using . allow the discovery of a collection of genes and molecular targets involved in neurodegeneration and other neuronal alterations following toxicological insult. Here we provide a synopsis of the findings on the cholinergic and dopaminergic systems of the CNS, using . as an animal model.
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