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Titlebook: Parasites, Fungi, and Viruses; J. D. Williams,A. M. Geddes Book 1976 Springer Science+Business Media New York 1976 cancer.chemotherapy.kin

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书目名称Parasites, Fungi, and Viruses
编辑J. D. Williams,A. M. Geddes
视频video
丛书名称Chemotherapy
图书封面Titlebook: Parasites, Fungi, and Viruses;  J. D. Williams,A. M. Geddes Book 1976 Springer Science+Business Media New York 1976 cancer.chemotherapy.kin
描述The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease. Each meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, expansion has been rapid, for example in cephalosporins, pen­ icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untoward effects arise; reduction of host toxicity without loss of antitumour activity by new substances occupies wide attention. The improved results with cancer chemotherapy, es­ pecially in leukaemias, are leading to a greater prevalence of severe infection in patients so treated, pharmacokinetics of drugs in normal and diseased subjects is receiving increasing attention along with related problems of bioavailability and interactions between drugs. Meanwhile the attack on some of the major bacterial infections, such as gonorrhoea and tubercu­ losis, which were among the first infections to feel the impact of chemotherapy, still continue to be major world problems and are now under attack with new agents and new methods. From this wide field and the 1,00
出版日期Book 1976
关键词cancer; chemotherapy; kinetics; pharmacokinetics; research; resistance; toxicity
版次1
doihttps://doi.org/10.1007/978-1-4684-3129-2
isbn_softcover978-1-4684-3131-5
isbn_ebook978-1-4684-3129-2
copyrightSpringer Science+Business Media New York 1976
The information of publication is updating

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Pharmacokinetic and Metabolic Studies with Ornidazole in Man. Comparison with Metronidazole,re labelled with .C in position 2 of the imidazole ring. They were administered orally at a dose of 750 mg and at an interval of 2 to 4 weeks to the same 4 adult volunteers. Additional pharmacokinetic studies of ornidazole with single high doses of the drug were carried out with cold material.
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What Are the Problems in Tropical Infections?,leprosy and tuberculosis — and some of the more recent successes attributable to chemotherapy will be presented in the middle section. But one of the scourges has gone and each one still represents either a continuing pool of misery and debility or a threat of another decimating epidemic. We have no cause for complacency.
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New 5-Nitroimidazoles with Antiprotozoal Activity: Effect of Hoe 088 (Pirinidazole),ichomonacidal effect. None of the compounds tested could prevent the formation of abscesses in all animals at the dose of 4 times 100 mg/kg. After administration of Hoe 088 the smallest number of abscesses was counted. The next in order were the Tinidazol- and finally the Metronidazoletreated animals.
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,The Efficiency of Metronidazole ‘Flagyl’* Against , in vivo, antrycide in the form of methyl sulphate or chloride salts, have greatly brightened the picture. However, antrycide is less effective against .. . and .. On the other hand, dimidium bromide is ineffective against ., . and ..
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Polyenes: Actions and Prospects,tuation for fungal infections is complicated by the fact that both parasite and host are eukaryotic organisms and the metabolic and structural differences which might provide a basis for chemotherapeutic attack result from variations on the same basic theme (Table 1).
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ach meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, expansion has been rapid, for example in cephalosporins, pen­ icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untowa
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