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Titlebook: Oxygen Homeostasis and Its Dynamics; Yuzuru Ishimura (Professor and Chairman),Hideo Shi Conference proceedings 1998 Springer-Verlag Tokyo

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Coupling of Ion and Charge Movements: From Peroxidases to Protonmotive Oxidasestive mechanism of oxidases. Three residues in subunit I of cytochrome oxidase that are likely to interfere with such protonations have been examined by mutagenesis, and the data are discussed in the light of the known crystal structures.
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Respiration of ,-Type Cytochrome , Oxidase, and Inhibition of NADH Oxidation by O,m with a . of 0.9 µM (. of about 250). Yeast cytochrome . and .,.,.′,.′-tetramethyl p-phenylene diamine (TMPD) also were oxidized at similar maximal velocities with larger .s. The effect of O. on inactivation of NADH oxidase activity of membranes during incubation was also examined.
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The Regulation by ATP of the Catalytic Activity and Molecular State of , Cytochrome , Oxidaseferrocytochrome c catalyzed by the dimeric oxidase is sigmoidal. On addition of ATP, the molecular mass of the dimeric oxidase becomes half and the -v curve changes to a hyperbola from a sigmoid. Thus, ATP regulates the molecular states and catalytic properties of the oxidase.
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