Titlebook: Oxidative Damage to Nucleic Acids; Mark D. Evans,Marcus S. Cooke Book 2007 Springer-Verlag New York 2007 Aging.Carcinogenesis.DNA.Neurolog

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脾气暴躁的人

Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage,ity and it is one of the most biologically important targets of ROS.. Oxidative DNA lesions are believed to be a major type of endogenous damage leading to human degenerative disorders including cancer, cardiovascular disease and brain dysfunction. The clinical features of inherited human DNA repair

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OGG1: From Structural Analysis to the Knockout Mouse,-oxoguanine (8-oxoG) is certainly the lesion that has retained most attention over many years. This altered base can pair with A as well as C residues during replication. Eukaryotic cells use a specific DNA glycosylase, 8-oxoG DNA glycosylase (OGG1), to excise 8-oxoG from DNA, and repair-deficient c

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SEED

Oxidative Damage and Promoter Function,r function. Such lesions have the capacity to interfere with normal gene regulation through direct interactions with promoter elements, or indirectly by establishing new transcription factor (TF) binding sites. The direct “cis” effects are the most studied and offer the best evidence for oxidative d

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Oxidative Damage and Repair in the Mitochondrial Genome,result in cellular dysfunction, including uncontrolled cell proliferation. Thus, in order to maintain the integrity of the genome, a complex network of DNA repair pathways exists to remove the majority of deleterious lesions. However, DNA repair may occasionally fail or become limited due to an exce

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Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases,rosis. The cellular and molecular mechanisms involved in atherosclerosis and its acute complications are being defined, but much is still unknown. Growing evidence indicates that oxidative damage to nuclear and mitochondrial DNA may represent an important link between the inflammatory nature and the

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Oxidative DNA Damage and Carcinogenesis,xygen species (ROS) that damage DNA on a continuous basis. Therefore, it is likely that ROS are the most important human carcinogens..An involvement of oxidative DNA damage, particularly 8-hydroxy-7, 8-dihydroguanine (8-OHGua) in the origin and/or progression of cancer is reviewed. It is concluded t