Titlebook: Ovarian Cancer; State of the Art and George Coukos,Andrew Berchuck,Robert Ozols Conference proceedings 2008 The Editor(s) (if applicable) a

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Defective Apoptosis Underlies Chemoresistance in Ovarian Cancer of ovarian cancer will be diagnosed, with the majority of these being advanced disease (stage III or stage IV). Survival varies by age, with overall 1-year and 5-year survival rates for new ovarian cancer patients of 76% and 45%, respectively (1). Survival rates drop dramatically with increasing st

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Nanoparticle Delivery of Suicide DNA for Epithelial Ovarian Cancer Therapyel plus a platinum-based therapy (cisplatin or carboplatin). Although ∼80% of patients receiving this therapeutic regimen have an initial favorable response, recurrent disease will occur in a majority of cases. Regrettably, there are currently no effective therapies for those patients with advanced-

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Biological Therapy with Oncolytic Herpesvirustrains have been genetically engineered, which replicate selectively within tumor cells. Examples include replication-competent mutants of herpes virus, adenovirus, vesicular stomatitis virus, reovirus, and measles virus (2, 17, 37, Martuza, 2000; 56, 63). In particular, replication-competent recomb

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Biological Therapy with Oncolytic Herpesvirusions less likely; (c) antiherpetic drugs are commercially available, which may be used clinically to control undesired side effects, should local or systemic spread of the virus occur; and (d) because of its large genome, HSV offers ample packaging opportunities – up to 30 kb – without affecting viral replication in cancer cells.

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MicroRNA in Human Cancer: One Step Forward in Diagnosis and Treatmentdence shows that miRNAs may play an important role in tumor development, and a better understanding of their alteration in cancer genome and oncogenic property should contribute to the diagnosis and treatment of cancer.