Titlebook: Orotic Acid; Synthesis, Biochemic Alois Čihák,Werner Reutter Book 1980 A.?ihák and W. Reutter 1980 biosynthesis.carbohydrate.cells.efficien

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Orotic Acid in Human Therapylearance of orotic acid approaches that of creatinine [433], and during drug-induced orotic aciduria it exceeds glomerular filtration [434]. There is evidence that even high doses of orotic acid are not deleterious to human individuals except that they may occasionally obstruct urine flow by forming crystalline deposits [435].

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New Growth Factor?ommercial powdered milk [2] have a relatively high content of orotic acid (50–100 mg 1. and 100–130 mg per 100 g protein respectively) human milk contains only trace amounts of orotic acid [3,4]. Its concentration in other foods is not yet known. There are several reports dealing with the amount of

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Aggregation of Enzymes of the Orotate Pathwayase activity. Also under a variety of physiological conditions both enzymes show closely parallel, co-ordinate changes in activity [120–122]. Orotate phosphoribosyltransferase from murine leukaemia P 1534 J (utilizing as the substrate orotate and 5-fluorouracil) was found to exist as a complex with

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Efficiency and Regulation of Pyrimidine Synthesis than 90-fold by a combination of PRPP and a heat labile factor [150], probably orotate phosphoribosyltransferase. It is assumed [151] that the enzyme attaches to the cell membrane and in the presence of external orotic acid and PRPP leads to the formation of internal orotidine 5′-phosphate. In bact

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Inhibitors of the Orotate Pathwayacts as a competitive inhibitor of orotidylic acid decarboxylase [247]. Therapeutic use of 6-azauridine [248,249] is occasionally complicated by a pronounced crystalluria. Owing to the block of orotidylic acid decarboxylase, large amounts of orotidine and orotic acid are excreted in urine. After the

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Induction of Fatty Liver in Ratsct is species specific and does not seem to occur in humans. The deposition of triglycerides in the liver, accompanied by a decrease in the concentration of plasma lipids, is a common and characteristic feature of fatty liver induced by various drugs. The earliest biochemical change [291,292] detect