Titlebook: Organotypic Models in Drug Development; Monika Schäfer-Korting,Silvya Stuchi Maria-Engler, Book 2021 Springer Nature Switzerland AG 2021 o

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Neural In Vitro Models for Studying Substances Acting on the Central Nervous Systeme.g., interspecies variation are reflected in the high number of drug attrition rates, especially in central nervous system (CNS) diseases. Therefore, human-based neural in vitro models for studying safety and efficacy of substances acting on the CNS are needed. Human iPSC-derived cells offer such a

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Skin Disease Models In Vitro and Inflammatory Mechanisms: Predictability for Drug Developmenty reproducibility and predictability. Traditionally, such models include animal models, mainly rodents, and cellular models. While animal models are highly useful in many studies, they are being replaced by human cellular models in more and more approaches amid recent technological development due t

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Tissue Engineering for Musculoskeletal Regeneration and Disease Modelingd up novel approaches to repair musculoskeletal defects in a fast and/or efficient manner. Biomaterials, cells, and signaling molecules constitute the tissue engineering triad. In the past 40 years, significant progress has been made in developing and optimizing all three components, but only a very

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The CAM Assay as an Alternative In Vivo Model for Drug Testingti-cancer drug effects. Literature about the CAM assay as an alternative in vivo cancer xenograft model according to the 3R principles has exploded in the last 3 years. Following a summary of the basic knowledge about the chicken embryo, we compare advantages and disadvantages with the classical mou

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unexpected given the nature of research in these disciplines but the need to obtain and process large amounts of data, to gather this from disparate locations and then to link and disseminate this information in a manner that challenges researchers and informs the wider public which is both a challe

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