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Titlebook: Organometallics as Catalysts in the Fine Chemical Industry; Matthias Beller,Hans-Ulrich Blaser Book 2012 Springer-Verlag Berlin Heidelberg

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978-3-642-44258-2Springer-Verlag Berlin Heidelberg 2012
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Organometallics as Catalysts in the Fine Chemical Industry978-3-642-32833-6Series ISSN 1436-6002 Series E-ISSN 1616-8534
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Application of Ring-Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membby simultaneous and slow addition of ruthenium catalyst and the diene substrate. The strategy of using RCM in this cost-effective synthesis sets a new paradigm for the synthesis of several other macrocyclic HCV protease inhibitors at Merck Research Laboratories.
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Asymmetric Hydrogenation,d in the hydrogenation reactions. Described are large scale applications of Rh, Ru, and Ir complexes with chiral P^P, P^N and N^N ligands, either used as preformed, isolated complexes or as in situ-prepared catalyst precursors.
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