Titlebook: Organelles in Eukaryotic Cells; Molecular Structure Joseph M. Tager,Angelo Azzi,Ferruccio Guerrieri Book 1989 Plenum Press, New York 1989

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The Mitochondrial Respiratory Chainor life as it appears when a block of the respiratory chain is induced by deadly poisons, such as hydrogen sulfide or cyanide, or by the defective synthesis of some proteins, an event which is at the basis of many respiratory chain diseases (1).

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On the Cellular Mechanism of Action of Diphtheria ToxinThe cellular mechanism of action of these toxins can be conveniently divided into three steps: 1) binding to the cell surface, 2) membrane translocation, 3) modification of the cytoplasmic target (Middlebrook & Dorland, 1984).

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Biogenesis of Peroxisomesed to carry out its particular function in biosynthetic or degradative processes. These different functions are each mediated by specific proteins and most of them are unique for a certain type of organelle. It requires that newly synthesised proteins are routed to the organelles or membrane structures to which they belong.

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Synthesis and Import of Mitochondrial Proteins up by mitochondria where they are rendered functional. Most nuclear-coded mitochondrial proteins are synthesized as larger molecular weight precursors, which contain an amino-terminal extension. They are cleaved by a specific matrix protease upon translocation of the precursor into mitochondria (for Ref. see 1).

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Transport of Lipids and Proteins During Membrane Flow in Eukaryotic Cellsily at the endoplasmic reticulum. This implies that specific mechanisms must exist that determine the fate and distribution of these compounds among membranes. Obviously, this sets particular requirements to intracellular sorting and transport phenomena.

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